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(PubMed) Bitanihirwe BK, Cunningham MG

Meta-analyses and randomized trials generally show incremental gains: modest improvements in response rates or progression-free survival, and in some settings better tolerability, with limited evidence of major overall-survival improvement [108]

Lastly, the change from methionine to leucine at the 27th position is believed to help prevent methionine oxidation

So basically they also are more likely to get multiple sclerosis

Prompt parenteral administration of Vitamin B12 prevents progression of neurologic damage

Regulatory note: Both peptides are research chemicals, not FDA-approved (removed from 503A compounding Category 2 in Sept 2024